15% off first order with code: 1storder
Competitive Prices
15% OFF MULTI PACK
NAD+ (Nicotinamide Adenine Dinucleotide) is an important coenzyme found in every cell of the body, enhancing the energy produced by the food consumed.
Canada Scientists have discovered that NAD+ is essential for mitochondria, the part of your cells that acts like a powerhouse. Mitochondria produce ATP, which is a main source of energy for cells, and NAD+ plays a big role in this process.
NAD+ also helps repair DNA, controls which genes are active, and keeps your cells healthy. However, as we age, the amount of NAD+ in our bodies decreases. This drop has been linked to lower energy levels and diseases that often come with ageing.
Boosting NAD+ levels is now a hot topic in science. Studies show that increasing NAD+ can improve how the body makes energy, support healthy ageing, and might even help people live longer.
Buy NAD+ Peptide Vial Canada here – Available in 250mg & 500mg
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme that supports numerous biological functions. Its primary role lies in redox reactions, where it alternates between its oxidised (NAD+) and reduced (NADH) states to facilitate electron transfer. This mechanism is crucial for producing ATP, the main energy source for cells [2].
Studies show that NAD+ also activates sirtuins, a group of proteins that manage cellular health, ageing, and metabolism. These proteins rely on NAD+ to remove acetyl groups from other proteins, affecting gene expression and boosting resilience to stress [5].
Additionally, NAD+ plays a key role in DNA repair. It acts as a substrate for enzymes like PARPs (poly ADP-ribose polymerases), which identify and fix DNA damage.
Buy NAD+ Canada online from PharmaLabGlobal. You may need additional products to reconstitute your NAD+. Find the full range of peptide accessories here.
The effectiveness of NAD is being thoroughly investigated for its vital role in many potential health benefits, including:
NAD+ boosts energy production
NAD+ is a vital coenzyme found in every cell of the body, playing a pivotal role in various biological processes, particularly energy metabolism. As a key component of cellular respiration, NAD+ facilitates the transfer of electrons during biochemical reactions, contributing to the production of ATP (adenosine triphosphate) — the cell’s primary energy source. Additionally, Canada scientists have found that NAD plus is intricately involved in DNA repair, gene expression, and cellular signalling, making it a fundamental element in maintaining overall cellular health [2].
NAD+ supports DNA mechanisms
NAD+ supports DNA repair mechanisms by serving as a crucial substrate for PARP enzymes, which identify and repair DNA damage. When DNA breaks occur, PARP enzymes use NAD+ to form poly(ADP-ribose) chains, signalling the repair machinery to the damage site. This process helps maintain genomic stability and prevent mutations, ensuring the integrity and proper function of the cells [3].
NAD+ can protect against oxidative stress
Canada Clinical studies have found that NAD+ plays a critical role in protecting against oxidative stress by participating in redox reactions, where it alternates between its oxidized (NAD+) and reduced (NADH) forms to neutralize free radicals. By supporting cellular antioxidant defense systems, NAD+ helps regenerate essential antioxidants, such as glutathione, which detoxify harmful reactive oxygen species. This process reduces oxidative damage to cells, thereby promoting cellular health and longevity [2].
NAD+ can slow down the ageing process
The presence of NAD could slow down the aging process by activating sirtuins, a family of proteins that regulate cellular health and longevity. Additionally, research suggests that NAD+ supports DNA repair mechanisms, ensuring genomic stability and reducing the accumulation of age-related mutations. By maintaining optimal cellular function and mitigating oxidative stress, NAD plus promotes overall cellular health, contributing to a slower and healthier aging process [7].
NAD+ can improve cognitive function
NAD+ supplementation may improve cognitive performance by enhancing energy metabolism, ensuring that brain cells have sufficient ATP to function optimally. It also protects neurons from damage by reducing oxidative stress and supporting cellular repair mechanisms. Additionally, NAD+ plays a role in the synthesis of neurotransmitters, which are crucial for efficient communication between neurons, thereby enhancing cognitive functions such as mental clarity, memory, and focus [4].
Furthermore, some Canada clinical investigations have found that NAD+ might protect against Alzheimer’s disease by reducing oxidative stress, which helps prevent neuronal damage and maintain brain health. It supports neuronal health by promoting the repair of damaged cells and enhancing mitochondrial function, crucial for energy production in brain cells. Moreover, NAD+ aids in DNA repair, helping to prevent the accumulation of mutations that can contribute to neurodegenerative conditions, such as Alzheimer’s [8].
NAD+ enhances muscle function and endurance
NAD+ enhances muscle function and endurance by improving energy production, thereby ensuring muscles have an ample supply of ATP during physical activity. It supports mitochondrial function, enabling optimal energy metabolism efficiency and reducing the buildup of lactic acid that causes muscle fatigue. By maintaining optimal cellular energy levels, NAD+ helps muscles perform better and recover faster, thereby boosting overall endurance [9].
Does NAD plus have any side effects?
Taking NAD+ supplements is usually well-tolerated, but some people might notice mild adverse effects like feeling a bit nauseous, tired, or getting headaches or an upset stomach. If you’re using injections, you might also find the injection site gets slightly irritated. These aren’t things everyone will experience, but it’s good to know they can happen. Before you start any new supplement, contact a healthcare provider or a pharmacist for advice.
PharmaLabGlobal supplies NAD+ in 250 mg & 500mg vials for research purposes only. Buy NAD+ today!
Is Niacin the same as NAD?
Niacin and NAD are connected, but they’re not the same thing. Niacin, also called vitamin B3, is like the raw material your body uses to make NAD (nicotinamide adenine dinucleotide). When you take in niacin, your body transforms it into NAD—a super important coenzyme that helps with things like producing energy and repairing DNA. Think of niacin as the building block your body needs to create NAD and keep things running smoothly.
Does the FDA approve NAD+ supplements?
NAD plus supplements are not explicitly approved by the FDA for the treatment or prevention of any diseases. In the United States, dietary supplements, including those containing NAD+ or its precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), are regulated as food products rather than drugs.
Can NAD+ have an effect on insulin sensitivity?
NAD supplements have been studied for their potential effects on insulin sensitivity. Scientists have discovered that enhancing NAD levels might help improve insulin sensitivity by boosting how mitochondria function and how the body manages energy. This could be especially helpful for people with type 2 diabetes, where insulin resistance is a major challenge.
NAD+ also plays a role in activating enzymes like sirtuins, which are associated with better metabolic health and improved insulin sensitivity. However, while these findings are promising, more research is needed to fully understand the extent of NAD+’s impact on insulin sensitivity in humans.
[1] Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
[2] Amjad S, Nisar S, Bhat AA, Shah AR, Frenneaux MP, Fakhro K, Haris M, Reddy R, Patay Z, Baur J, Bagga P. Role of NAD+ in regulating cellular and metabolic signaling pathways. Mol Metab. 2021 Jul;49:101195.
[3] Ruszkiewicz JA, Bürkle A, Mangerich A. Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity. J Biol Chem. 2022 Jun;298(6):102037.
[4] Zhao Y, Zhang J, Zheng Y, Zhang Y, Zhang XJ, Wang H, Du Y, Guan J, Wang X, Fu J. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. J Neuroinflammation. 2021 Sep 16;18(1):207.
[5] Goody MF, Henry CA. A need for NAD+ in muscle development, homeostasis, and aging. Skelet Muscle. 2018 Mar 7;8(1):9.
[6] Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71.
[7] de Guia RM, Agerholm M, Nielsen TS, Consitt LA, Søgaard D, Helge JW, Larsen S, Brandauer J, Houmard JA, Treebak JT. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle. Physiol Rep. 2019 Jul;7(12):e14139.
[8] Yao Z, Yang W, Gao Z, Jia P. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci Lett. 2017 Apr 24;647:133-140.
[9] Li Y, Dash RK, Kim J, Saidel GM, Cabrera ME. Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies. Am J Physiol Cell Physiol. 2009 Jan;296(1):C25-46.
How Does Aging Affect NAD+ Levels in the Body?
This article from PharmaLabGlobal discusses the role of NAD+ in maintaining cellular health, promoting energy production, and enabling DNA repair. It highlights how NAD+ levels decline with age in the human body, leading to reduced mitochondrial function, slowing metabolism, and increasing cellular stress. The blog details the potential of NAD+ peptides in research to replenish these levels, improve metabolic pathways, and support anti-aging efforts.
The Power of NAD+ Peptide for Neurological Disorders
PharmaLabGlobal explores the potential of the use of NAD+ supplements in addressing conditions like Alzheimer’s, Parkinson’s, and brain injuries. It highlights how this peptide could restore cellular energy, protect neurons from oxidative stress, and enhance cognitive function. By boosting NAD+ levels, they may enhance brain cell repair, reduce inflammation, and improve memory and focus.
Protective Power of NAD+ Against Alzheimer’s Disease
Delve into how the powerhouse supplement NAD+ reduces oxidative stress, thereby protecting neurons from damage, and supports neuronal health through enhanced mitochondrial function and cellular repair. Additionally, it highlights NAD+’s crucial role in the body’s natural defences of DNA repair, preventing the accumulation of mutations that can lead to Alzheimer’s.
Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)
At Pharma Lab Global we supply premium peptides to the research industry worldwide.
Our mission and priority are to ensure that clients receive a superior customer experience.
At Pharma Lab Global we aim to supply the highest purity research peptides at affordable prices.
ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY
DISCLAIMER: All products sold by Pharma Lab Global are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.
